Multifunctional polyphenol-based silk hydrogel alleviates oxidative stress and enhances endogenous regeneration of osteochondral defects

Multifunctional polyphenol-based silk hydrogel alleviates oxidative stress and enhances endogenous regeneration of osteochondral defects

In osteochondral defects, oxidative stress caused by elevated levels of reactive oxygen species (ROS) can disrupt the normal endogenous repair process. In this study, a multifunctional hydrogel composed of silk fibroin (SF) and tannic acid (TA), the FDA-approved ingredients, was developed to allevia...

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Bibliographic Details
Main Authors: Cao, Z. (Author), Chen, J. (Author), Chi, J. (Author), Li, X. (Author), Ling, C. (Author), Mo, Q. (Author), Sheng, R. (Author), Wang, H. (Author), Yao, Q. (Author), Zhang, W. (Author), Zhang, Y. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Bone
Cell culture
Cell death
Cell proliferation
Controlled drug delivery
Defects
Elevated level
Flavonoids
Hydrogel
Hydrogels
Hydrogen bonds
Microenvironment
Microenvironments
Osteochondral defects
Osteochondral regeneration
Osteochondral regenerations
Oxidative stress
Polyphenols
Reactive oxygen species
Repair process
Silk fibroin
Silk hydrogels
Stem cells
Tannic acid
Tannins
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