A Selective β−Catenin-Metadherin/CEACAM1-CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor–Macrophage Interaction

A Selective β−Catenin-Metadherin/CEACAM1-CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor–Macrophage Interaction

Tumor heterogeneity plays a key role in cancer relapse and metastasis, however, the distinct cellular behaviors and kinetics of interactions among different cancer cell subclones and the tumor microenvironment are poorly understood. By profiling an isogenic model that resembles spontaneous human ova...

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Bibliographic Details
Main Authors: Chan, K.K.L (Author), Ip, P.P.C (Author), Shi, J. (Author), Tang, M.K.S (Author), To, S.K.Y (Author), Tong, Y. (Author), Wong, A.S.T (Author), Zhang, J. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
Cancer cells
Cell membranes
Cell signaling
Cellular behaviors
cytokinesis
Cytokinesis
Cytology
Diseases
Macrophages
Mammals
ovarian cancer
Ovarian cancers
Pathology
polyploid
Polyploid
Subclones
Tumor heterogeneity
Tumor microenvironments
tumor-associated macrophages
Tumors
Tumour-associated macrophages
β-catenin
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