The interaction between ceramide-1-phosphate and Group IVA cytosolic phospholipase A2 and its role in wound healing

The interaction between ceramide-1-phosphate and Group IVA cytosolic phospholipase A2 and its role in wound healing

The sphingolipid, ceramide-1-phosphate (C1P), directly binds and activates Group IVA cytosolic phospholipase A2 (cPLA2a) to generate eicosanoids. Due to the role of eicosanoids in wound healing, we choose to use our novel genetic mouse model expressing cPLA2a with an ablated C1P interaction site (KI...

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Bibliographic Details
Main Author:	MacKnight, Patrick
Format:	Others
Published:	VCU Scholars Compass 2018
Subjects:	cellular migration dermal fibroblasts wound tensile strength collagen inflammation Biochemistry Molecular Biology
Online Access:	https://scholarscompass.vcu.edu/etd/5633 https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=6717&context=etd

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