EXPLORING THE CONCEPT OF HUMAN OCT3 INHIBITORS AS A NOVEL CLASS OF ANTIDEPRESSANTS
The Dukat laboratory developed 2-amino-6-chloro-3,4-dihydroquinazoline (A6CDQ) as a 5-HT3 receptor ligand. A6CDQ and one of its positional isomers, the 7-chloro analog A7CDQ, produced antidepressant-like effects in the mouse tail suspension test (TST). We investigated and systematically ruled out a...
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VCU Scholars Compass
2016
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| Online Access: | http://scholarscompass.vcu.edu/etd/4607 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=5674&context=etd |