Enhancement of the Placental Transmission of Lopinavir Using a Transporter Targeted Prodrug Strategy
Lopinavir (LPV) is a potent protease inhibitor specific for HIV-1. However, LPV has poor placental penetration due to substrate activity for efflux transporter by P-glycoprotein (P-gp). Since fatty acid transporters are highly expressed in the placenta during pregnancy, we designed fatty acid ester...
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VCU Scholars Compass
2015
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Online Access: | http://scholarscompass.vcu.edu/etd/3973 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=4992&context=etd |