Enhancement of the Placental Transmission of Lopinavir Using a Transporter Targeted Prodrug Strategy

Lopinavir (LPV) is a potent protease inhibitor specific for HIV-1. However, LPV has poor placental penetration due to substrate activity for efflux transporter by P-glycoprotein (P-gp). Since fatty acid transporters are highly expressed in the placenta during pregnancy, we designed fatty acid ester...

Full description

Bibliographic Details
Main Author: Wang, Meng
Format: Others
Published: VCU Scholars Compass 2015
Subjects:
HIV
Online Access:http://scholarscompass.vcu.edu/etd/3973
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=4992&context=etd