Interplay between Artemis and TDP1 in sensitivity to radiomimetic agents
DNA double-strand breaks containing unligatable termini are potent cytotoxic lesions leading to cell death or growth arrest. Artemis, which is associated with the Non-Homologous End Joining (NHEJ) pathway, is the major end processing nuclease that resolves unligatable termini, especially the 3′ bloc...
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| Format: | Others |
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VCU Scholars Compass
2015
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| Online Access: | http://scholarscompass.vcu.edu/etd/3755 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=4772&context=etd |