Involvement of p53 in the S-phase Checkpoint during Nucleotide Deficiencies

Involvement of p53 in the S-phase Checkpoint during Nucleotide Deficiencies

Several classes of antimetabolites have been developed for the treatment of cancer, including numerous inhibitors of nucleotide biosynthesis. N-(phosphonacetyl)-L-aspartate (PALA) and hydroxyurea (HU) are two antimetabolites that inhibit nucleotide biosynthesis; PALA inhibits de novo pyrimidine syn...

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Bibliographic Details
Main Author: Heyer, Cortney
Format: Others
Published: VCU Scholars Compass 2011
Subjects:
p53
nucleotide deficiency
S-phase
checkpoint
post-translational modifications
TAP tag
Medical Pharmacology
Medical Sciences
Medicine and Health Sciences
Online Access:http://scholarscompass.vcu.edu/etd/2439
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=3438&context=etd

Internet

http://scholarscompass.vcu.edu/etd/2439
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=3438&context=etd

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