The Transcriptional Regulation of HLA-E by Interferon-Gamma in Tumor Cells
The human Class Ib gene, HLA-E inhibits both Natural Killer Cells and a subset of CD8+ cytotoxic T lymphocytes by engaging the CD94/NKG2A inhibitory receptor. IFN-γ induces the expression of HLA-E as well as Class Ia molecules, which are required for the killing of target cells. Since HLA-E has nega...
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| Format: | Others |
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VCU Scholars Compass
2010
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| Online Access: | http://scholarscompass.vcu.edu/etd/2261 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=3260&context=etd |