Age-Related Differences in In-vitro Sensitivity to Inhibition of Human Red Blood Cell Acetylcholinesterase and Plasma Butyrylcholinesterase by the Cholinesterase Inhibitors Physostigmine (PHYS), Pyridostigmine (PYR), Donepezil (DON) and Galantamine (GAL)

Age-Related Differences in In-vitro Sensitivity to Inhibition of Human Red Blood Cell Acetylcholinesterase and Plasma Butyrylcholinesterase by the Cholinesterase Inhibitors Physostigmine (PHYS), Pyridostigmine (PYR), Donepezil (DON) and Galantamine (GAL)

Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder, characterized clinically by a progressive loss of memory, cognitive function, ability to care for oneself and psychiatric symptoms. First-line agents for the treatment of AD are ChE inhibitors (DON, GAL), whose modest cli...

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Bibliographic Details
Main Author: Lee, David
Format: Others
Published: VCU Scholars Compass 2009
Subjects:
acetylcholinesterase
butyrylcholinesterase
cholinesterase inhibitors
aging
in-vitro sensitivity
physostigmine
galantamine
donepezil
pyridostigmine
red blood cell
plasma
age-related
suicide inactivator
competitive inhibitors
noncompetitive inhibitors
mechanism-based inhibitor
inhibitor models
enzyme kinetics
inhibitor kinetics
Alzheimer’s disease
myathenia gravis
Medicine and Health Sciences
Pharmacy and Pharmaceutical Sciences
Online Access:http://scholarscompass.vcu.edu/etd/1937
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=2936&context=etd

Internet

http://scholarscompass.vcu.edu/etd/1937
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=2936&context=etd

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