The Role of the Propeptide and its Residues in Activation and Secretion of Elastase, an M4 Metalloprotease Secreted by Pseudomonas aeruginosa

Pseudomonas aeruginosa secretes several proteases associated with pathogenesis, but the most abundant and active is elastase (M4 metalloendopeptidase). Elastase (lasB), is first synthesized as a preproenzyme, with a signal peptide, an 18-kDa N-terminal propeptide, and a 33-kDa mature domain. The pr...

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Bibliographic Details
Main Author: Boice, Emily
Format: Others
Published: VCU Scholars Compass 2011
Subjects:
Online Access:http://scholarscompass.vcu.edu/etd/217
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1216&context=etd

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