The Role of the Propeptide and its Residues in Activation and Secretion of Elastase, an M4 Metalloprotease Secreted by Pseudomonas aeruginosa
Pseudomonas aeruginosa secretes several proteases associated with pathogenesis, but the most abundant and active is elastase (M4 metalloendopeptidase). Elastase (lasB), is first synthesized as a preproenzyme, with a signal peptide, an 18-kDa N-terminal propeptide, and a 33-kDa mature domain. The pr...
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VCU Scholars Compass
2011
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| Online Access: | http://scholarscompass.vcu.edu/etd/217 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1216&context=etd |