P53 mediated cell motility in H1299 lung cancer cells
Studies have shown that gain-of- function mutant p53, AKT, and NFκB promote invasion and metastasis in tumor cells. Signals transduced by AKT and p53 are integrated via negative feedback between the two pathways. Tumor derived p53 was also indicated to induce NFκB gene expression. Due to the close r...
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VCU Scholars Compass
2010
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| Online Access: | http://scholarscompass.vcu.edu/etd/109 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1108&context=etd |