In Vivo Genotoxicity and Selection Associated with Thiopurine Treatment in Subjects with Inflammatory Bowel Disease

Thiopurines azathioprine and 6-mercaptopurine are effective immune-modulators and cytotoxic agents widely used in the treatment of autoimmune diseases, graft rejection, and cancer. Of concern is the growing epidemiologic evidence that chronic exposure to these agents increases the risk of mesench...

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Bibliographic Details
Main Author: Nguyen, Truc
Format: Others
Published: ScholarWorks @ UVM 2008
Subjects:
Online Access:http://scholarworks.uvm.edu/graddis/160
http://scholarworks.uvm.edu/cgi/viewcontent.cgi?article=1159&context=graddis