Investigation Into the Role of the C-Terminal Vicinal Cysteine Residues in High MR Thioredoxin Reductases
Mammalian thioredoxin reductase (TR) contains the rare amino acid selenocysteine (Sec), which is essential for the enzyme’s catalytic activity. Substitution of the catalytic Sec residue for a cysteine (Cys) residue, results in a drop in kcat of 100- fold. Homologous high molecular weight TRs from ot...
| Main Author: | |
|---|---|
| Format: | Others |
| Published: |
ScholarWorks @ UVM
2008
|
| Subjects: | |
| Online Access: | http://scholarworks.uvm.edu/graddis/130 http://scholarworks.uvm.edu/cgi/viewcontent.cgi?article=1129&context=graddis |