Synthetic investigation of small-molecule probes

A series of small molecules was synthesized to probe three protein targets in order to elucidate the key small molecule-protein interactions required for potency. Triclosan is an antibacterial compound that has surfaced as a potential environmental hazard and is hypothesized to cause perturbations i...

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Bibliographic Details
Main Author: Bromba, Caleb
Other Authors: Wulff, Jeremy Earle
Language:English
en
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/1828/4354