Structural and biochemical investigation of the regulation of Rab11a by the guanine nucleotide exchange factors SH3BP5 and TRAPPII
Rab11 is a critical GTPase involved in the regulation of membrane trafficking in the endocytic pathway, and it’s misregulation is involved in a variety of human diseases including Huntington’s disease and Alzheimer’s disease. Additionally, de novo mutations (DNMs) of Rab11 have been identified in pa...
Main Author: | Jenkins, Meredith L. |
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Other Authors: | Burke, John E |
Format: | Others |
Language: | English en |
Published: |
2019
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Subjects: | |
Online Access: | http://hdl.handle.net/1828/11343 |
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