Alterations of the epigenome in brain cancer: loss of 5-hydroxymethylcytosine
Abstract : 5-Methylcytosine is an epigenetic mark, which can be oxidized to 5-hydroxymethylcytosine (5hmC) in DNA by ten-eleven translocation (TET) oxygenases. It is an initial step in the demethylation of 5mC. Levels of 5hmC is relatively high in the brain compared to other organs, but these levels...
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| Language: | English |
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Université de Sherbrooke
2017
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| Online Access: | http://hdl.handle.net/11143/9864 |