Role of the human chymase (CMA1) in the conversion of big-endothelin-1 to endothelin-1 (1-31)

Abstract : The chymase-dependant pathway responsible for converting Big ET-1 to ET-1 was established in vitro. It has only been recently, in 2009, that our group demonstrated that the conversion of Big ET-1 to ET-1 (1-31) can occur in vivo in mice (Simard et al., 2009), knowing that ET-1 (1-31) is...

Full description

Bibliographic Details
Main Author: Semaan, Walid
Other Authors: D'Orléans-Juste, Pedro
Language:English
Published: Université de Sherbrooke 2016
Subjects:
Online Access:http://hdl.handle.net/11143/9806