Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection

Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection

Chronic HCV infection causes generalized CD8+T cell impairment, not limited to HCV-specific CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory (M1)...

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Bibliographic Details
Main Author: Ahmed, Faria
Other Authors: Kumar, Ashok
Format: Others
Language:en
Published: Université d'Ottawa / University of Ottawa 2018
Subjects:
HCV
Hepatitis C
Chronic Infection
Immunology
Innate
Adaptive
Macrophages
T cells
Immune Response
Online Access:http://hdl.handle.net/10393/38227
http://dx.doi.org/10.20381/ruor-22481

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