Investigating the Role of Sirtuin 1 in the Pulmonary Vascular Response to Chronic Hypoxia-Induced Pulmonary Hypertension

Investigating the Role of Sirtuin 1 in the Pulmonary Vascular Response to Chronic Hypoxia-Induced Pulmonary Hypertension

Background: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by increased pulmonary artery pressure, leading to right ventricle hypertrophy and ultimately heart failure and death. Sirtuin 1 (SIRT1) is an NAD+ dependent protein deacetylase that has been strongly implicated...

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Bibliographic Details
Main Author: Taha, Mohamad
Other Authors: Stewart, Duncan John
Format: Others
Language:en
Published: Université d'Ottawa / University of Ottawa 2018
Subjects:
Sirtuin 1
Pulmonary hypertension
Chronic hypoxia
SIRT1
Transgenic mice
Endothelial cells
Hypoxia inducible factors
Online Access:http://hdl.handle.net/10393/37550
http://dx.doi.org/10.20381/ruor-21819

Internet

http://hdl.handle.net/10393/37550
http://dx.doi.org/10.20381/ruor-21819

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