Characterization of the Molecular Mechanism by which SMN Regulates mRNA Translation

Despite our understanding of the role of the survival motor neuron protein (SMN) in cytoplasmic small ribonucleoproteins (snRNP) assembly, it is unclear how loss of this protein causes motor neuron degeneration in Spinal Muscular Atrophy (SMA). It could be explained by defects in functions that are...

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Bibliographic Details
Main Author: Mostefai, Fatima
Other Authors: Côté, Jocelyn
Language:en
Published: Université d'Ottawa / University of Ottawa 2017
Subjects:
SMN
Online Access:http://hdl.handle.net/10393/37057
http://dx.doi.org/10.20381/ruor-21329