Structural and Biochemical Dissection of the KMT2 Core Complex

Histone H3 lysine 4 (H3K4) methylation is an evolutionarily conserved mark commonly associated with transcription activation in eukaryotes. In mammals, this post-translational modification is deposited by the KMT2 family of H3K4 methyltransferases. Biochemical studies have shown that the enzymatic a...

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Bibliographic Details
Main Author: Zhang, Pamela Peng
Other Authors: Couture, Jean-François
Language:en
Published: Université d'Ottawa / University of Ottawa 2015
Subjects:
Online Access:http://hdl.handle.net/10393/32479
http://dx.doi.org/10.20381/ruor-4754