Systems Regulating and Inducing Dopaminergic Cell Death in Parkinson’s Disease: an Analysis of Signalling Associated with Parkinson's Disease Models

Parkinson’s disease (PD) is characterized by the progressive loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Mechanisms regulating this neurodegeneration, however, are unclear. Evidence from PD pathology and models of PD, indicate mitochondrial disfunction triggers several...

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Bibliographic Details
Main Author: Mount, Matthew P.
Other Authors: Park, David
Language:en
Published: Université d'Ottawa / University of Ottawa 2015
Subjects:
Online Access:http://hdl.handle.net/10393/32053
http://dx.doi.org/10.20381/ruor-2755