Synthesis of A-CD Estrogens with Potential for Hormone Replacement Therapy. Isolation of Sesquiterpene Lactones from Neurolaena lobata and Diterpenoids from Leretia cordata
The use of estrogen supplements by postmenopausal women has been associated with increased risks of uterine and breast cancer. There are two possible mechanisms of toxicity: estradiol can promote breast cancer cell proliferation through estrogen receptor-α (ERα) and get metabolized to genotoxic ort...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2013
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| Online Access: | http://hdl.handle.net/10393/26262 http://dx.doi.org/10.20381/ruor-3313 |