Computational Methods for Inferring Transcription Factor Binding Sites

Computational Methods for Inferring Transcription Factor Binding Sites

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Position weight matrices (PWMs) have become a tool of choice for the identification of transcription factor binding sites in DNA sequences. PWMs are compiled from experimentally verified and aligned binding sequences. PWMs are then used to computationally discover novel putative binding sites for a...

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Bibliographic Details
Main Author: Morozov, Vyacheslav
Other Authors: Aris-Brosou, Stéphane
Language:en
Published: Université d'Ottawa / University of Ottawa 2012
Subjects:
machine learning
transcriptional regulatory sites
transcription factor
protein binding
PWM
PSSM
DNA sequence
optimization
statistics
binding site
prediction
computational methods
Matthews correlation
Drosophila melanogaster
binding motif
weight matrix
DNA sequence analysis
Online Access:http://hdl.handle.net/10393/23382
http://dx.doi.org/10.20381/ruor-6117

Internet

http://hdl.handle.net/10393/23382
http://dx.doi.org/10.20381/ruor-6117

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