Overcoming the Current Limitations of Next-Generation Sequencing with New Methods for Local Assembly of Genomes and High-Specificity Rare Mutation Detection
The relatively low cost of Next-Generation Sequencing (NGS) has enabled researchers to generate large amounts of sequencing data in order to identify disease-causing mutations and to assemble simple genomes. However, NGS has inherent limitations due to the short DNA read lengths and high error rate...
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| Language: | en_US |
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University of Oregon
2016
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| Online Access: | http://hdl.handle.net/1794/19700 |