Molecular Mechanisms for the Evolution of DNA Specificity in a Transcription Factor Family

Transcription factors (TFs) bind to specific DNA sequences near target genes to precisely coordinate their regulation. Despite the central role of transcription factors in development and homeostasis, the mechanisms by which TFs have evolved to bind and regulate distinct DNA sequences are poorly und...

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Bibliographic Details
Main Author: McKeown, Alesia
Other Authors: Prehoda, Kenneth
Language:en_US
Published: University of Oregon 2015
Subjects:
Online Access:http://hdl.handle.net/1794/18723