Evasion of Tak1-p38α/β-Stat1/2 non-canonical Activin A signalling leads to aberrant mouse prostate epithelial cell proliferation in vitro and in vivo.
Tgf-β ligands induce cell cycle arrest in a variety of mammalian epithelia, including in the prostate. Genetic deregulation of the downstream canonical Smad-dependent pathway is an early well-studied event in tumorigenesis, yet, in prostate cancer such mutations are rare, leaving unexplained how Tgf...
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| Format: | Doctoral Thesis |
| Language: | English |
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Università degli studi di Trento
2020
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| Online Access: | http://hdl.handle.net/11572/266240 |