Epigenetic changes promoting HeLa cell apoptosis are linked to valproic acid-induced down-regulation of REST and its corepressor CoREST

REST (RE-1 silencing transcription factor, or NRSF –neuron-restrictive silencing factor) binds to a conserved RE-1 motif present in the promoter region of regulated genes and represses their transcription in neuronal and non-neuronal cells (Bruce et al., 2004). REST recruits corepressors (CoREST, mS...

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Bibliographic Details
Main Author: Khodeneva, Natalya <1988>
Other Authors: Spampinato, Santi Mario
Format: Doctoral Thesis
Language:en
Published: Alma Mater Studiorum - Università di Bologna 2016
Subjects:
Online Access:http://amsdottorato.unibo.it/7651/