Epigenetic changes promoting HeLa cell apoptosis are linked to valproic acid-induced down-regulation of REST and its corepressor CoREST
REST (RE-1 silencing transcription factor, or NRSF –neuron-restrictive silencing factor) binds to a conserved RE-1 motif present in the promoter region of regulated genes and represses their transcription in neuronal and non-neuronal cells (Bruce et al., 2004). REST recruits corepressors (CoREST, mS...
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Format: | Doctoral Thesis |
Language: | en |
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Alma Mater Studiorum - Università di Bologna
2016
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Online Access: | http://amsdottorato.unibo.it/7651/ |