Autocrine and paracrine effects of BRAF inhibitor induced senescence in melanoma
The FDA approval of targeted therapy with BRAFV600E inhibitors like vemurafenib and dabrafenib in 2011 has been the first major breakthrough in the treatment of metastatic melanoma since almost three decades. Despite increased progression free survival and elevated overall survival rates, complete r...
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| Format: | Doctoral Thesis |
| Language: | English |
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2019
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| Online Access: | https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/18116 http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181161 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-181161 https://opus.bibliothek.uni-wuerzburg.de/files/18116/Grimm_Johannes_Dissertation.pdf |