Effect of amyloid precursor protein and tau on dendritic spines and cell survival in an ex vivo model of Alzheimer s disease
Alzheimer s disease is characterized by synaptic alterations and neurodegeneration. Histopathological hallmarks represent amyloidplaques composed of amyloid-beta (Abeta) and neurofibrillary tangles containing hyperphosphorylated tau. To determine whether synaptic changes and neurodegeneration share...
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| Format: | Doctoral Thesis |
| Language: | English |
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2009
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| Online Access: | https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2009121414 |