CDK4 Rescues Diabetes in IRS2-Deficient Mice: Exploring Novel Roles of a Cell Cycle Regulator in Promoting Beta Cell Differentiation

CDK4 Rescues Diabetes in IRS2-Deficient Mice: Exploring Novel Roles of a Cell Cycle Regulator in Promoting Beta Cell Differentiation

Strategies aimed at expanding functional beta cell mass remain a prime goal of diabetes research. Both the insulin signaling pathway, as well as the G1/S transition of the cell cycle are critically important for the maintenance of beta cell mass. We previously demonstrated in a mouse model of diabet...

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Bibliographic Details
Main Author:	Stamateris, Rachel E.
Format:	Others
Published:	eScholarship@UMMS 2021
Subjects:	beta cell diabetes insulin proliferation differentiation IRS2 FOXO1 PDX1 HDACs SIRT1 Biology Cell Biology Endocrine System Diseases
Online Access:	https://escholarship.umassmed.edu/gsbs_diss/1138 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2148&context=gsbs_diss

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