CDK4 Rescues Diabetes in IRS2-Deficient Mice: Exploring Novel Roles of a Cell Cycle Regulator in Promoting Beta Cell Differentiation
Strategies aimed at expanding functional beta cell mass remain a prime goal of diabetes research. Both the insulin signaling pathway, as well as the G1/S transition of the cell cycle are critically important for the maintenance of beta cell mass. We previously demonstrated in a mouse model of diabet...
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| Format: | Others |
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eScholarship@UMMS
2021
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/1138 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2148&context=gsbs_diss |