ER Stress and ATF6alpha potently induce S-Phase in Old Mouse Beta Cells Cultured Ex-Vivo in High Glucose

ER Stress and ATF6alpha potently induce S-Phase in Old Mouse Beta Cells Cultured Ex-Vivo in High Glucose

Aging is associated with a loss of proliferation of the insulin-secreting beta cell, a possible contributing factor to the greatly increased rate of type-2 diabetes in the elderly. A landmark study from our lab previously illustrated that mild endoplasmic reticulum (ER) stress drives beta cell proli...

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Bibliographic Details
Main Author:	Snyder, Jarin T.
Format:	Others
Published:	eScholarship@UMMS 2020
Subjects:	Aging diabetes islets senescence quiescence regeneration UPR Atf6 proliferation Biotechnology Endocrine System Diseases Medical Cell Biology Molecular Biology Nutritional and Metabolic Diseases
Online Access:	https://escholarship.umassmed.edu/gsbs_diss/1125 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2134&context=gsbs_diss

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