ER Stress and ATF6alpha potently induce S-Phase in Old Mouse Beta Cells Cultured Ex-Vivo in High Glucose

ER Stress and ATF6alpha potently induce S-Phase in Old Mouse Beta Cells Cultured Ex-Vivo in High Glucose

Aging is associated with a loss of proliferation of the insulin-secreting beta cell, a possible contributing factor to the greatly increased rate of type-2 diabetes in the elderly. A landmark study from our lab previously illustrated that mild endoplasmic reticulum (ER) stress drives beta cell proli...

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Bibliographic Details
Main Author: Snyder, Jarin T.
Format: Others
Published: eScholarship@UMMS 2020
Subjects:
Aging
diabetes
islets
senescence
quiescence
regeneration
UPR
Atf6
proliferation
Biotechnology
Endocrine System Diseases
Medical Cell Biology
Molecular Biology
Nutritional and Metabolic Diseases
Online Access:https://escholarship.umassmed.edu/gsbs_diss/1125
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2134&context=gsbs_diss

Internet

https://escholarship.umassmed.edu/gsbs_diss/1125
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2134&context=gsbs_diss

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