Differential TCR signaling dynamics tune graded gene expression in early-activating CD8+ T cells
The strength of peptide:MHC interactions with the T cell receptor (TCR) is correlated with the time to first cell division, the relative scale of the effector cell response, and the graded expression of activation-induced proteins. The TCR proximal tyrosine kinase ITK simultaneously influences many...
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| Format: | Others |
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eScholarship@UMMS
2020
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/1115 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2125&context=gsbs_diss |