Structural Mechanism of Substrate Specificity In Human Cytidine Deaminase Family APOBEC3s
APOBEC3s (A3s) are a family of human cytidine deaminases that play important roles in both innate immunity and cancer. A3s protect host cells against retroviruses and retrotransposons by deaminating cytosine to uracil on foreign pathogenic genomes. However, when mis-regulated, A3s can cause heteroge...
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| Format: | Others |
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eScholarship@UMMS
2020
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/1079 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2084&context=gsbs_diss |