Akt Regulation of Mdm2-p53 Signaling in Cellular Stress Responses and Tumorigenesis
In cells undergoing stress, the p53 transcription factor is stabilized and activates the expression of numerous genes contributing to p53-mediated tumor suppression. One p53 target gene is Mdm2, which encodes an oncoprotein that binds and ubiquitinates p53 for proteasomal degradation, thus limiting...
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| Format: | Others |
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eScholarship@UMMS
2019
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/1028 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2037&context=gsbs_diss |