Synthesis of chiral vicinal diamines and in vitro anticancer properties of their platinum(II) coordinates

Synthesis of chiral vicinal diamines and in vitro anticancer properties of their platinum(II) coordinates

15N-based nuclear magnetic resonance techniques are considered very powerful to study the molecular properties of platinum-containing anticancer agents, these properties being responsible for the efficacy of the compounds, but also for the understanding of resistance mechanisms and toxicity. Therefo...

Full description

Bibliographic Details
Main Author: Berger, Gilles
Other Authors: Dufrasne, François
Format: Doctoral Thesis
Language:en
Published: Universite Libre de Bruxelles 2013
Subjects:
Sciences pharmaceutiques
Platinum
Antineoplastic agents
Cancer > Chemotherapy
Platine
Anticancéreux
Cancer > Chimiothérapie
G-quadruplexes
infrared spectroscopy
cancer
platinum complexes
density functional theory
organic synthesis
Online Access:http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209376

Internet

http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209376

Similar Items