SYNTHESIS AND EVALUATION OF PROUTEOLYSIS TAURGETING CHIMERAS (PROTACs): A POTENTIAL CHEMICAL GENETIC APPROACH TO BREAST CANCER THERAPY
The use of small molecules to probe the function of proteins is referred to as chemical genetics. The Proteolysis Targeting Chimera (PROTAC) is a chemical genetic tool that contains the ligand for a target protein of interest and the recognition motif for an E3 ubiquitin ligase attached by a linker....
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| Format: | Others |
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UKnowledge
2009
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| Online Access: | http://uknowledge.uky.edu/gradschool_diss/773 http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1776&context=gradschool_diss |