COMPUTATIONAL DESIGN OF 3-PHOSPHOINOSITIDE DEPENDENT KINASE-1 INHIBITORS AS POTENTIAL ANTI-CANCER AGENTS

COMPUTATIONAL DESIGN OF 3-PHOSPHOINOSITIDE DEPENDENT KINASE-1 INHIBITORS AS POTENTIAL ANTI-CANCER AGENTS

Computational drug design methods have great potential in drug discovery particularly in lead identification and lead optimization. 3-Phosphoinositide dependent kinase-1 (PDK1) is a protein kinase and a well validated anti-cancer target. Inhibitors of PDK1 have the potential to be developed as anti-...

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Bibliographic Details
Main Author: AbdulHameed, Mohamed Diwan Mohideen
Format: Others
Published: UKnowledge 2009
Subjects:
Drug design|3-Phosphoinositide dependent kinase-1 (PDK1)|Celecoxib binding mode|3D-QSAR models|Ligand-based|structure-based virtual screening
Pharmacy and Pharmaceutical Sciences
Online Access:http://uknowledge.uky.edu/gradschool_diss/757
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1760&context=gradschool_diss

Internet

http://uknowledge.uky.edu/gradschool_diss/757
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1760&context=gradschool_diss

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