STUDIES ON THE ROLE OF ACID SPHINGOMYELINASE AND CERAMIDE IN THE REGULATION OF TACE ACTIVITY AND TNFα SECRETION BY MACROPHAGES
Acid Sphingomyelinase (ASMase) activity has been proposed to mediate LPS signaling in various cell types. This study shows that in macrophages, ASMase is a negative regulator of LPS-induced TNFα secretion. ASMasedeficient (asm-/-) mice and isolated peritoneal macrophages produce several fold more TN...
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| Format: | Others |
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UKnowledge
2009
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| Online Access: | http://uknowledge.uky.edu/gradschool_diss/741 http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1744&context=gradschool_diss |