LIPID-BASED PACLITAXEL AND DOXORUBICIN NANOPARTICLES TO OVERCOME P-GP-MEDIATED DRUG RESISTANCE IN SOLID TUMORS

LIPID-BASED PACLITAXEL AND DOXORUBICIN NANOPARTICLES TO OVERCOME P-GP-MEDIATED DRUG RESISTANCE IN SOLID TUMORS

Multidrug resistance (MDR) is a major obstacle limiting chemotherapeutic efficacy. The purpose of these studies was to investigate the potential application of injectable paclitaxel (PX) and doxorubicin (Dox)-loaded nanoparticles (NPs) engineered from oil-in-water microemulsion precursors for overco...

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Bibliographic Details
Main Author: Dong, Xiaowei
Format: Others
Published: UKnowledge 2009
Subjects:
Nanoparticles|Cancer|Enhanced permeability and retention (EPR) effect|Experimental design|ATP
Pharmacy and Pharmaceutical Sciences
Online Access:http://uknowledge.uky.edu/gradschool_diss/724
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1727&context=gradschool_diss

Internet

http://uknowledge.uky.edu/gradschool_diss/724
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1727&context=gradschool_diss

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