DRUG MILK TO SERUM RATIO PREDICTION AND ONTOGENY OF CYP3A CLEARANCE PATHWAY AS A MODEL OF DRUG EXPOSURE IN THE DEVELOPING RAT
Transfer of drugs into milk and the clearance of drugs in neonates are critical determinants of the exposure of infants to drugs in breast milk. Models predicting both parameters have been proposed. The objective of this dissertation is to test two models predicting milk to serum ratio and an ontoge...
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| Format: | Others |
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UKnowledge
2007
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| Online Access: | http://uknowledge.uky.edu/gradschool_diss/532 http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1535&context=gradschool_diss |