ISOPRENOID ANALOGS AS CHEMICAL GENETIC TOOLS TO PROVIDE INSIGHTS INTO FARNESYL TRANSFERASE TARGET SELECTION AND CELLULAR ACTIVITY

ISOPRENOID ANALOGS AS CHEMICAL GENETIC TOOLS TO PROVIDE INSIGHTS INTO FARNESYL TRANSFERASE TARGET SELECTION AND CELLULAR ACTIVITY

Protein farnesylation is an essential post-translational modification required for the function of numerous cellular proteins including the oncoprotein Ras. The farnesyl transferase (FTase) catalyzed reaction is unique because farnesyl diphosphate (FPP), the farnesyl group donor for the reaction, fo...

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Bibliographic Details
Main Author: Troutman, Jerry
Format: Others
Published: UKnowledge 2006
Subjects:
Protein Farnesyl Transferase
Enzyme Kinetics
Prenyl Transferases
Solid-Phase Organic Synthesis
Hapten Synthesis
Medical Biochemistry
Online Access:http://uknowledge.uky.edu/gradschool_diss/212
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1215&context=gradschool_diss

Internet

http://uknowledge.uky.edu/gradschool_diss/212
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1215&context=gradschool_diss

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