LOSS OF BLOOM SYNDROME PROTEIN CAUSES DESTABILIZATION OF GENOMIC ARCHITECTURE AND IS COMPLEMENTED BY ECTOPIC EXPRESSION OF Escherichia coli RecG IN HUMAN CELLS

LOSS OF BLOOM SYNDROME PROTEIN CAUSES DESTABILIZATION OF GENOMIC ARCHITECTURE AND IS COMPLEMENTED BY ECTOPIC EXPRESSION OF Escherichia coli RecG IN HUMAN CELLS

Genomic instability driven by non-allelic homologous recombination (NAHR) provides a realistic mechanism that could account for the numerous chromosomal abnormalities that are hallmarks of cancer. We recently demonstrated that this type of instability could be assayed by analyzing the copy number va...

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Bibliographic Details
Main Author: Killen, Michael Wayne
Format: Others
Published: UKnowledge 2011
Subjects:
Bloom’s Syndrome
BLM
homologous recombination
genomic instability
cancer
Biochemistry
Cell Biology
Genetics
Online Access:http://uknowledge.uky.edu/gradschool_diss/201
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1204&context=gradschool_diss

Internet

http://uknowledge.uky.edu/gradschool_diss/201
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1204&context=gradschool_diss

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