THE DISORDERED REGULATION OF CALCINEURIN: HOW CALMODULIN-INDUCED REGULATORY DOMAIN STRUCTURAL CHANGES LEAD TO THE ACTIVATION OF CALCINEURIN

THE DISORDERED REGULATION OF CALCINEURIN: HOW CALMODULIN-INDUCED REGULATORY DOMAIN STRUCTURAL CHANGES LEAD TO THE ACTIVATION OF CALCINEURIN

Calcineurin (CaN) is a highly regulated Ser/Thr protein phosphatase that plays critical roles in learning and memory, cardiac development and function, and immune system activation. Alterations in CaN regulation contribute to multiple disease states such as Down syndrome, cardiac hypertrophy, Alzhei...

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Bibliographic Details
Main Author: Dunlap, Victoria B
Format: Others
Published: UKnowledge 2013
Subjects:
Calcineurin
Calmodulin
Calcium Signaling
Intrinsically Disordered Protein
Folding Upon Binding
Biochemistry
Biophysics
Structural Biology
Online Access:http://uknowledge.uky.edu/biochem_etds/9
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1009&context=biochem_etds

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http://uknowledge.uky.edu/biochem_etds/9
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1009&context=biochem_etds

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