A new dynamic model for non-viral multi-treatment gene delivery systems for bone regeneration: parameter extraction, estimation, and sensitivity
In this thesis we develop new mathematical models, using dynamical systems, to represent localized gene delivery of bone morphogenetic protein 2 into bone marrow-derived mesenchymal stem cells and rat calvarial defects. We examine two approaches, using pDNA or cmRNA treatments, respectively, towards...
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| Format: | Others |
| Language: | English |
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University of Iowa
2019
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| Online Access: | https://ir.uiowa.edu/etd/6996 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=8497&context=etd |