Structure and function of the disordered regions within translesion synthesis DNA polymerases

Normal DNA replication is blocked by DNA damage in the template strand. Translesion synthesis is a major pathway for overcoming these replication blocks. In this process, multiple non-classical DNA polymerases form a complex at the stalled replication fork called the mutasome. This complex is struct...

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Bibliographic Details
Main Author: Powers, Kyle Thomas
Other Authors: Washington, M. Todd
Format: Others
Language:English
Published: University of Iowa 2018
Subjects:
Online Access:https://ir.uiowa.edu/etd/6625
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=8124&context=etd