Structural and dynamic determinants of inhibitor specificity among regulators of G protein signaling
Regulator of G Protein Signaling 4 (RGS4) mediates motor defects in Parkinson's disease. Small molecule RGS4 inhibitors (e.g. CCG-50014) modify buried cysteine residues, but the structural and dynamic mechanisms underpinning specificity of inhibitors for RGS4 within the RGS family are poorly un...
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| Format: | Others |
| Language: | English |
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University of Iowa
2016
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| Online Access: | https://ir.uiowa.edu/etd/3099 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=6443&context=etd |